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Thermo Scientific RNase T1 is an endoribonuclease that specifically degrades single-stranded RNA at G residues (see Figure 1 in Supporting Data). It cleaves the phosphodiester bond between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotides with the formation of corresponding intermediate 2', 3'-cyclic phosphate (see Reference 1). The reaction products are 3'-GMP and oligonucleotides with a terminal 3'-GMP.
RNase T1 does not require metal ions for activity.
RNase T1 activity.